FLAG: Multi-pass Transmembrane Proteins and Technology Platforms eBook

Multi-pass transmembrane proteins found on the cell membrane are accountable for cell protection, external and internal material transport, and transmitting signals. These include the maintenance and support of the cell membrane structure, the transportation of waste and nutrients, cell-to-cell signaling based on ions, hormones, neurotransmitters, and other mediators, and chemical reactions with substrates like exogenous substances, polypeptides, metabolites, and proteins.

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The importance and diversity of multi-pass transmembrane protein functions make them critical targets in drug development. Over 50% of all drugs on the market today comprise human multi-pass transmembrane proteins, which include CD20, G Protein-coupled receptors (GPCRs), ion channels, nuclear receptors, transporters, etc.

High-quality antigens are crucial for developing therapies and drugs that target multi-pass transmembrane proteins. In CD20, various drugs recognize different fragments of the CD20 extracellular domain, which emphasizes the significance of the full-length CD20 protein in developing CD20-targeted drugs and therapies.

This free eBook from FLAG- an ACRO Biosystems brand, presents an overview of technology platforms for multi-pass transmembrane proteins.

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